ഡെക്സാമെഥസോൺ

ഡെക്സാമെഥസോൺ
Clinical data
Trade names	Dextenza, Ozurdex, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682792
License data	EU EMA: by INN; US DailyMed: Dexamethasone;
Pregnancy; category	AU: A; ;
Routes of; administration	By mouth, intravenous therapy (IV), intramuscular injection (IM), subcutaneous injection (IM), intraosseous (IO), eye drop
ATC code	A01AC02 (WHO) C05AA09 (WHO), D07AB19 (WHO), D10AA03 (WHO), H02AB02 (WHO), R01AD03 (WHO), S01BA01 (WHO), S02BA06 (WHO), S03BA01 (WHO);
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Bioavailability	80–90%
Protein binding	77%
Metabolism	Liver
Elimination half-life	190 minutes (3.2 hours)
Excretion	Urine (65%)
Identifiers
	IUPAC name (8S,9R,10S,11S,13S,14S,16R,17R)-9- Fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17- dodecahydro-3H-cyclopenta[a]phenanthren-3-one;
CAS Number	50-02-2 ;
PubChem CID	5743;
IUPHAR/BPS	2768;
DrugBank	DB01234 ;
ChemSpider	5541 ;
UNII	7S5I7G3JQL;
KEGG	D00292 ;
ChEBI	CHEBI:41879 ;
ChEMBL	ChEMBL384467 ;
PDB ligand	DEX (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID3020384 ;
ECHA InfoCard	100.000.004
Chemical and physical data
Formula	C22H29FO5
Molar mass	392.461 g/mol g·mol−1
3D model (JSmol)	Interactive image;
Melting point	262 °C (504 °F)
	SMILES O=C(CO)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)CC[C@H]4[C@@H]2C[C@H]3C)C)C;
	InChI InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1 ; Key:UREBDLICKHMUKA-CXSFZGCWSA-N ;
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ഒരു കോർട്ടിക്കോ സ്റ്റീറോയ്ഡ് മരുന്നാണ് ഡെക്സാമെഥസോൺ(Dexamethasone) .^[1] സന്ധിവാതം, ചർമ്മരോഗങ്ങൾ, അലർജി, ആസ്മ, ക്രൂപ്പ്, മസ്തിഷ്കവീക്കം, കോവിഡ്-19, നേത്രശസ്ത്രകിയയുടെ ഫലമായുണ്ടാകുന്ന കണ്ണുവേദന, ക്ഷയം എന്നിവയ്ക്ക് ഈ മരുന്ന് നൽകപ്പെടുന്നു.^[1]

അവലംബം

↑ ^1.0 ^1.1 "Dexamethasone". The American Society of Health-System Pharmacists. Archived from the original on 2017-08-31. Retrieved Jul 29, 2015.

[AHFS2015-1] 1.0 ^1.1 "Dexamethasone". The American Society of Health-System Pharmacists. Archived from the original on 2017-08-31. Retrieved Jul 29, 2015.

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